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Protective effect of metformin on rat diabetic retinopathy involves suppression of toll-like receptor 4/nuclear factor-k B expression and glutamate excitotoxicity

(eds) Physician's Guide to the Diagnosis, Treatment, and Follow-Up of Inherited Metabolic Diseases

They suppress appetite, making it easier to eat less without feeling deprived, and they improve blood sugar regulation, which is one reason they were originally developed for diabetes treatment

The common thread: none of these work in isolation, and none of them replace the fundamentals (caloric deficit, protein, training, sleep)

Pasternak B, Wintzell V, Hviid A, Eliasson B, Gudbjornsdottir S, Jonasson C, et al